Cross-sectional and longitudinal study protocols of the ‘ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents’ (ADIBOX) project
Identifieur interne : 002144 ( Main/Exploration ); précédent : 002143; suivant : 002145Cross-sectional and longitudinal study protocols of the ‘ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents’ (ADIBOX) project
Auteurs : Elodie Chaplais [France, Australie] ; Frédéric Dutheil [France, Australie] ; Geraldine Naughton [Australie] ; David Greene [Australie] ; Bruno Pereira [France] ; David Thivel [France] ; Daniel Courteix [France, Australie]Source :
- BMJ Open [ 2044-6055 ] ; 2016.
Abstract
A need exists for sustainable and clinically effective weight management interventions, suitable for preventing well-linked chronic disease such as diabetes and cardiovascular disease and some less investigated secondary conditions such as bone alteration. The ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents (ADIBOX) protocol was designed to provide a better understanding of the interaction between adipokines and bone hormones in adolescents with obesity and how a 10-month physical activity programme may affect these interactions.
The ADIBOX protocol combines 2 studies. The first study involves a total of 68 adolescents aged 12–16 years. This cross-sectional study will include both males and females (1:1 ratio), either living with obesity/overweight (n=34; body mass index (BMI) ≤97th centile and ≥85th centile) or normal weight (n=34; BMI<85th centile). The second study is a longitudinal study that will include 50 obese adolescent girls and track them over a period of 42 weeks. Weight loss programme will consist of a combination of physical activity and a normocaloric diet. Bone and adiposity-related measurements will be performed every 14 weeks. Both studies will assess participants' anthropometric profile, nutrition and physical activity, body composition, bone densitometry and blood markers of bone, growth and adiposity.
The ADIBOX protocol complies with the ethics guidelines for clinical research and has been approved by their respective ethics committee (Australian Catholic University Committee Ethic, Australia and Hospital Sud Est 1 committee, France). Findings from this protocol are expected to clarify the possible interactions between adiposity and bone in childhood obesity and will be disseminated at several research conferences and published articles in peer-reviewed journals.
Url:
DOI: 10.1136/bmjopen-2016-011407
PubMed: 27797988
PubMed Central: 5073595
Affiliations:
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The ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents (ADIBOX) protocol was designed to provide a better understanding of the interaction between adipokines and bone hormones in adolescents with obesity and how a 10-month physical activity programme may affect these interactions.</p></sec><sec><title>Methods and analysis</title><p>The ADIBOX protocol combines 2 studies. The first study involves a total of 68 adolescents aged 12–16 years. This cross-sectional study will include both males and females (1:1 ratio), either living with obesity/overweight (n=34; body mass index (BMI) ≤97th centile and ≥85th centile) or normal weight (n=34; BMI<85th centile). The second study is a longitudinal study that will include 50 obese adolescent girls and track them over a period of 42 weeks. Weight loss programme will consist of a combination of physical activity and a normocaloric diet. Bone and adiposity-related measurements will be performed every 14 weeks. Both studies will assess participants' anthropometric profile, nutrition and physical activity, body composition, bone densitometry and blood markers of bone, growth and adiposity.</p></sec><sec><title>Ethics and dissemination</title><p>The ADIBOX protocol complies with the ethics guidelines for clinical research and has been approved by their respective ethics committee (Australian Catholic University Committee Ethic, Australia and Hospital Sud Est 1 committee, France). Findings from this protocol are expected to clarify the possible interactions between adiposity and bone in childhood obesity and will be disseminated at several research conferences and published articles in peer-reviewed journals.</p></sec><sec><title>Trial registration number</title><p><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02626273">NCT02626273</ext-link>; Pre-results.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Daniels, S" uniqKey="Daniels S">S Daniels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ebbeling, Cb" uniqKey="Ebbeling C">CB Ebbeling</name></author><author><name sortKey="Pawlak, Db" uniqKey="Pawlak D">DB Pawlak</name></author><author><name sortKey="Ludwig, Ds" uniqKey="Ludwig D">DS Ludwig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, M" uniqKey="Ng M">M 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Obert</name></author><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campos, Rm" uniqKey="Campos R">RM Campos</name></author><author><name sortKey="De Mello, Mt" uniqKey="De Mello M">MT de Mello</name></author><author><name sortKey="Tock, L" uniqKey="Tock L">L Tock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Bergh, J" uniqKey="Van Den Bergh J">J Van den Bergh</name></author><author><name sortKey="Noordam, C" uniqKey="Noordam C">C Noordam</name></author><author><name sortKey="Ozyilmaz, A" uniqKey="Ozyilmaz A">A Özyilmaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damilakis, J" uniqKey="Damilakis J">J Damilakis</name></author><author><name sortKey="Adams, Je" uniqKey="Adams J">JE Adams</name></author><author><name sortKey="Guglielmi, G" uniqKey="Guglielmi G">G Guglielmi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Chaplais, Elodie" sort="Chaplais, Elodie" uniqKey="Chaplais E" first="Elodie" last="Chaplais">Elodie Chaplais</name></noRegion><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Pereira, Bruno" sort="Pereira, Bruno" uniqKey="Pereira B" first="Bruno" last="Pereira">Bruno Pereira</name><name sortKey="Thivel, David" sort="Thivel, David" uniqKey="Thivel D" first="David" last="Thivel">David Thivel</name><name sortKey="Thivel, David" sort="Thivel, David" uniqKey="Thivel D" first="David" last="Thivel">David Thivel</name></country><country name="Australie"><noRegion><name sortKey="Chaplais, Elodie" sort="Chaplais, Elodie" uniqKey="Chaplais E" first="Elodie" last="Chaplais">Elodie Chaplais</name></noRegion><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Greene, David" sort="Greene, David" uniqKey="Greene D" first="David" last="Greene">David Greene</name><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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